During the patent approval process, purdue research foundation prf, under the auspices of 37 c. Nucleus biologics the leader in precision cell culture. Explore medical and scientific journals discussing p4hb devices, including galatea scaffolds, as well as applications and outcomes. Tissue regenerative composition badylak, stephen f. Badylak, and based on similarities between his work and the work of dr. Us 8691276 b2 extracellular matrixderived gels and related. More particularly, the present invention is directed to non immunogenic tissue graft compositions comprising stomach submucosa and use of same to promote endogenous tissue growth. A consideration of the current law and public policy concerns regarding upstream patents vincent j. Badylak, dvm phd md, juan diego naranjo, md, and lindsey saldin. He also has assumed the role of chief scientific officer for a new startup company, ecm therapeutics, based on a group of patents developed in his lab. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion. Shaping may be accomplished mechanically by cuttingcarving a wafer to a desired shape.
The present invention relates to a tissue graft composition and methods for its preparation and use. Also provided are compositions prepared according to the methods as well as uses for the compositions. The use of the lens for this purpose, when used within a confocal microscope apparatus, greatly reduces image artifacts and creates an increased transfer efficiently between the light source and the sample. His research interests have focused on tissue engineering and regenerative medicine for the past 20 years. Patent statistics and patent portfolio valuations are excellent. Breaking a patent law and legal definition uslegal, inc. Methods for the preparation and use of injectable tissue graft compositions are described. The company has 16 issued patents broadly covering the technology and products.
Badylak assigned the 389 patent and the rights to other patents on inventions he had developed to prf. A water faucet control valve comprises a valve and a control section seating in an oval mixed chamber of the valve. Use clinical data for eu market approval and presubmission meeting with fda for pivotal clinical study and market approval strategy. He has served as the chair of several study sections at the national institutes of health nih. Badylak fi led papers under oath denying any inventorship in spievacks patents. A tampon, cylindrical shape, or conical shape may be made by selectively shaping the wafer described above. Us 8691276 b2 extracellular matrixderived gels and.
Matricryptic ecm peptides for tissue reconstruction the lens. Collectively, the 2018 nai fellows hold nearly 4,000 patents and represent over 120 institutions 9,400 licensed. Badylaks discoveries have been translated to medical applications that have helped millions of patients, and his intellectual property has contributed significantly to the multibilliondollar regenerative medicine industry. Neill jordon turner original assignee university of pittsburgh of the commonwealth system of higher education priority date the priority date is an assumption and is not a legal conclusion. A method for surgical reconstruction of a collagenous meniscus at the interface of articulating bones, said method comprising the step of surgically implanting into said interface a meniscus graft comprising a sheet of a first tissue graft composition comprising the tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warmblooded vertebrate. The hemostatic device described above may be applied to the anatomic site requiring hemostasis in the form of a gel, glue, foam, or spray. Tissue engineering regenerative medicine at the mcgowan. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate nonsubmucosal sources, added endothelial cells, and at least one additional preselected, exogenous population. Badylak began his academic career at purdue university in 1983, and subsequently held a variety of positions including service as the director of the hillenbrand biomedical engineering center from 1995 1998. A world leader in regenerative medicine technology cook. Badylak is a research professor in the department of surgery and. This listing includes patent applications that are pending as well as patents that have already been granted by the united states patent and trademark office uspto. Aug 18, 2006 the 389 patent names four inventors, one of whom is dr.
The integrity of patents affects the future health of people the world over. Badylak inventions, patents and patent applications. Wagner holds well over 10 issued patents and has many patent filings in the field of cardiovascular biomaterials, medical devices, imaging and tissue engineering. A world leader in regenerative medicine technology. Breaking a patent law and legal definition breaking a patent refers to the act of demonstrating or explaining that a patent is invalid or unenforceable because of its unlawful usage by the patentee or improper issuance by the u. The tissue graft construct comprises a tissue material comprising submucosa selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts. Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. University of pittsburgh team of alex almarza, phd, stephen badylak, dvm, phd, md, william chung, dds, md, and bryan brown phd is developing an extracellular matrix ecm based sca.
Provided are methods for preparing gelled, solubilized extracellular matrix compositions useful as cell growth scaffolds. Spievack and accused them both of patent infringement. Us5516533a fluidized intestinal submucosa and its use as. Such patentpaper pairs are at the heart of our empirical strategy. The invention provides a composition conditioned for the remodeling, restoration, repair, or replacement of tissue within a host. Patent statistics and patent portfolio valuations are excellent sources of business information. Abstract a tissue graft construct for use in repairing diseased or damaged tissues is provided. The composition is conditioned by culturing cells on the matrix andor by exposing the cultured cells or matrix to one or more stressors. Badylak and four other purdue researchers be added as coinventors to spievacks patents. The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition. Badylak has filed for patents to protect the following inventions. Turner nj, yates aj, weber dj, qureshi ir, beer stolz d, gilbert tw, badylak sf.
Badylak christopher lee dearth timothy joseph keane, jr. Composition and method for repairing neurological tissue. Spievacks patent applications based on his work by demanding that the u. Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix ecm compositions useful as cell growth substrates. Galatea scaffolds are bioresorbable, monofilament, and constructed of poly4hydroxybutyrate p4hb biopolymer an advanced, biologically produced polymer. Multiple patents can be obtained by separating requests with a semicolon. The university of pittsburgh school of medicine and upmc health system have established the mcgowan institute for regenerative medicine which serves as a single base of operations for the universitys leading scientists and clinical. Prior to the filing of the purdue patent in question, dr. Most recent updates difference between current and previous stands are in italics last update. Provided herein are methods of making an ecm gel from vascular tissue. The 389 patent names four inventors, one of whom is dr. The valve comprises a pair of studs next to the chamber. Badylak has founded two companies and either chaired or been a member of the scienti.
He has also founded two biotech companies and currently serves as co. The tissue graft construct comprises a tissue material comprising submucosa selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts and hydrolysates thereof, added endothelial cells. Biologic scaffold remodeling in a dog model of complex musculoskeletal injury. Badylak and four other purdue researchers to spievacks patents. We exploit the fact that patents are granted with a substantial lag, often many years after the knowledge is initially disclosed through paper publication. Also provided herein are ecm compositions prepared from vascular tissue, and methods of use of those compositions, for example in treatment of aneurysms, and for vascularization or revascularization. Spievack and acell, a company founded by spievack, accusing them of patent infringement.
The extracellular matrix as a scaffold for tissue reconstruction. Conditioned compositions for tissue restoration patent. Badylak is a research professor in the department of surgery and director of the mcgowan center for preclinical studies at the mcgowan institute for regenerative medicine at the university of pittsburgh. Us5516533a fluidized intestinal submucosa and its use as an. Miramar, fl 33025 416 3642551 address, including zip code, and telephone number, including area code, of registrants principal executive offices. A method of preparing an extracellular matrixderived gel comprising. Design patents, patent patents, pregrant publications, reissues, and statutory invention registrations are all included. The post is adjustable relative to the seat such that the cap is adjustable up and down relative to the base. The repair putty has the potential to hospitalization time and reduced infections. An air fryer includes a base, a seat attached to the base, a post having a lower portion slidably received in the seat, an arm pivotally coupled to the upper portion of the post, and a cap secured to the arm for enclosing the base. The valve has an outlet for coldhotmixed water to flow there through. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
Vascularization enhanced graft constructs nz536563. This listing includes patent applications that are pending as well as patents that have already been. A confocal microscope comprises a focusing lens for focusing a light source onto a pin hole. He has authored more than 350 scientific publications and 40 book chapters and has recently edited a textbook entitled host response to biomaterials. Alan spievack, the purdue research foundation and cook biotech, the company who had licensed some of badylaks technology, sued dr. The composition comprises comminuted intestinal submucosa or proteasedigested intestinal submucosa. The ecm exists in a state of dynamic equilibrium with its adjacent cell population and is responsive to ever changing environmental conditions and the functional demands of the cells and their parent tissue or. Discover the potential of the epos legal patent information. Retina, the acne medicine that has become much talked about in recent years as a possible antiaging cream that smooths out facial wrinkles, is now the subject of a nasty patent battle. He has served as the chair of several study sections at the national institutes of health nih, and is currently a member. Badylak has prioritized clinical translation of his ideas, resulting in more than 40 of his patents being licensed to industry. Do formal intellectual property rights hinder the free.
A tissue graft construct for use in repairing diseased or damaged tissues is provided. Xenogeneic extracellular matrix as an inductive scaffold for regeneration of a. On february 9, 2003, prf granted cook an exclusive license with respect to many of its patents in this field of tissue. A fluidized, injectable tissue graft composition is described. Meeting recently in ottawa, health ministers from 30 countries pledged cooperation to curb any potential outbreak of. Eric marchewitz has filed for patents to protect the following inventions. Nucleus biologics provides us with a trusted source for our precision cell culture supplements, consistent with our dedication to the development of nextgeneration cellular immunotherapies. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues. Bill rodkey, dvm retired steadman philippon, vail, co savio woo, phd u.
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Nov 24, 2005 extracellular matrix is the product of the resident cells of each tissue and organ and serves both structural and functional roles. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis. Tissue graft for surgical reconstruction of a collagenous. Introduction this article focuses on patentability issues concerning biotechnology, with specific emphasis on the status of. Vascularization enhanced graft constructs patent europe pmc. University of pittsburgh team of alex almarza, phd, stephen badylak, dvm, phd, md, william chung, dds, md, and bryan brown phd is developing an extracellular matrix ecm based scaffold device for the reconstruction of the tmj. Durasis, dural substitute product from cook biotech, inc. A pair of pin holes are formed next to the water outlet. United states court of appeals for the federal circuit.
Unfortunately, one of the worlds rising economic players is leading the charge against patents. His research interests have focused on tissue engineering and regenerative medicine for the past 20. Feb 26, 2009 moreover, tissue regenerative composition of the invention can be applied in a form other than a sheet or multilayer sheet of material, for example, ubm may be applied as an extract, in gel form, powdered form, tubular form, sheet form, or as strips, cords or struts or mixed with other pharmaceutical agents, for example, growth factors and gene. He has prioritized clinical translation of his ideas, resulting in more than 40 of his patents being licensed to industry. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ecm is dispersed to. These totals include all patents and published applications in our index, but we cannot guarantee complete coverage. Galaflex, galashape 3d and galaform 3d galatea scaffolds are indicated for use as a bioresorbable scaffold for soft tissue support and to repair, elevate, and reinforce deficiencies where weakness or voids exist that require the addition of material to obtain the desired surgical outcome. Patent and trademark office, please enter your request in the format. University of pittsburgh faculty elected fellow of the. The devices comprise a sheet of naturally occurring extracellular.
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